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刘勇
 

姓名:刘勇

办公电话:0427-2631433

电子信箱:yliu@dlut.edu.cn

教育和工作经历:

2014-今   大连理工大学 教授

2010-2011 美国伊利诺伊大学芝加哥分校 博士后

2008-2010 美国芝加哥大学 博士后

2006-2013 中国科学院大连化学物理研究所 助理研究员、副研究员

2002-2006 中国科学院大连化学物理研究所生物化工专业 博士

1999-2002 大连医科大学劳动卫生与环境卫生专业 硕士

1994-2002 辽宁省抚顺市新抚卫生防疫站 医师、主管医师

1989-1994 中国医科大学预防医学专业 学士

研究领域(研究课题)

研究领域:

(1) 临床药理与个性化安全用药

(2) 药物代谢与药代动力学

(3) 毒理学

(4) 新药研发

科研课题:

(1) 人源细胞色素P450s酶催化特异性与多样性的机理研究,国家自然科学基金;

(2) 细胞色素P450酶非典型动力学的机制研究,国家自然科学基金;

(3) 基于新型体内探针的药物反应个体间差异标记物及检测试剂盒关键技术研究,“十二五”国家科技重大专项子课题;

(4) 肝癌个体化药物治疗指导研究,“十二五”国家科技重大专项子课题;

(5) 肝癌个体化药物治疗指导研究,“十一五”国家科技重大专项子课题;

(6) The Intestinal Bacterial Metabolites of Ginsenosides Could Enhance the Anticancer Effects of Docetaxel in Androgen-Independent Prostate Cancer Cells In vitro and In vivo.韩国人参协会项目。

出版著作和论文

发表文章:

2015

(1) Li W, Xing Y,Liu Y*. Inhibition of SN-38 glucuronidation by gefitinib and its metabolite. Cancer Chemother Pharmacol, 2015, 75(6):1253-60.

2014

(1) Wu J, Cao Y, Zhang Y,Liu Y, Hong JY, Zhu L, Ge G, Yang L. Deoxyschizandrin, a naturally occurring lignan, is a specific probe substrate of human cytochrome P450 3A.Drug Metabolism & Disposition, 2014;42(1):94-104.

(2) Li N, Wang D, Ge G, Wang X,Liu Y, Yang L. Ginsenoside metabolites inhibit p-glycoprotein in vitro and in situ using three absorption models.Planta Medica2014; 80(4):290-6.

(3) Ai L, Zhu L, Yang L, Ge G, Cao Y,Liu Y, Fang Z, Zhang Y. Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases.Xenobiotica. 2014;44(4):320-5.

(4) Zhang YY,Liu Y, Mehboob S, Song JH, Boci T, Johnson ME, Ghosh AK, Jeong H. Metabolism-directed structure optimization of benzimidazole-based Francisella tularensis enoyl-reductase (FabI) inhibitors.Xenobiotica, 2014, 44(5):404-16

2013年及以前

(1) Fang ZZ, Cao YF, Hu CM, Hong M, Sun XY, Ge GB,Liu Y, Zhang YY, Yang L, Sun HZ. Structure-inhibition relationship of ginsenosides towards UDP-glucuronosyltrans- ferases (UGTs).Toxicology and Applied Pharmacology. 2013, 267(2):149-54.

(2) Jiang HM, Fang ZZ, Cao YF, Hu CM, Sun XY, Hong M, Yang L, Ge GB,Liu Y, Zhang YY, Dong Q, Liu RJ. New insights for the risk of bisphenol A: Inhibition of UDP-glucuronosyltransferases (UGTs).Chemosphere. 2013;93(6):1189-93.

(3) Qi X, Liang S, Ge G,Liu Y, Dong P, Zhang J, Wang A, Hou J, Zhu L, Yang L, Tu C. Inhibitory effects of sanguinarine on human liver cytochrome P450 enzymes.Food and Chemical Toxicology, 2013, 56: 392–7.

(4) Wu JJ, Ai CZ,Liu Y, Zhang YY, Jiang M, Lv AP, Yang L. Interactions between Phytochemicals from Traditional Chinese Medicines and Human Cytochrome P450 Enzymes.Current Drug Metabolism, 2012, 13: 599-614.

(5) Zhu L, Ge G,Liu Y, He G, Liang S, Fang Z, Dong P, Cao Y, Yang L. Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9.Xenobiotica, 2012, 42(10): 1001-8.

(6) Zhu L, Ge G,Liu Y, Guo Z, Peng C, Zhang F, Cao Y, Wu J, Fang Z, Liang X, Yang L. Characterization of UDP-Glucuronosyltransferases Involved in Glucuronidation of Diethylstilbestrol in Human Liver and Intestine.Chemical Research in Toxicology, 2012; 25(12): 2663-9.

(7) Cao YF, He RR, Cao J, Chen JX, Huang T,Liu Y*. Drug-Drug Interactions Potential of Icariin and Its intestinal metabolites via Inhibition of Intestinal UDP-Glucurono- syltransferases.Evidence-Based Complementary and Alternative Medicine. 2012: 395912, doi:10.1155/2012/395912. (*通讯作者)

(8)Liu Y, Jeong H, Takahashi H, Drozda K, Patel SR, Shapiro NL, Nutescu EA, Cavallari LH.Decreased Warfarin Clearance Associated With the CYP2C9 R150H (*8) Polymorphism.Clinical Pharmacology & Therapeutics2012; 91(4): 660-5.

(9)Liu Y, Ramirez J, Ratain MJ. Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors.British Journal of Clinical Pharmacology, 2011, 71(6): 917–920.

(10) Li W,Liu Y, Li XX, Yu Y, Wu JJ, Wang Q, Huo H, Yang L, Wang LM. MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status.Planta Medica2011, 77(1):27-31.

(11) Wang AX, Hu Y, Liu HX, Qi XY,Liu Y, Tu CX, Yang L. C5-Hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2.Xenobiotica. 2011, 41(5):349-57.

(12) He YQ, Yang L, Liu HX, Zhang JW,Liu Y, Fong A, Xiong AZ, Lu YL, Yang L, Wang CH, Wang ZT. Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids.Chemical Research In Toxicology. 2010, 23(3):591-9.

(13) He YQ,Liu Y, Wang CH, Yang L, Liu HX, Zhang BF, Xu LL, Lu YL, Yang L, Wang ZT. Identification of the UDP-glucuronosyltransferase isozyme involved in senecionine glucuronidation in human liver microsomes.Drug Metabolism and Disposition, 2010, 38(4):626-34.

(14)Liu Y, Ramirez J, House L, Ratain MJ. The UGT1A1*28 Polymorphism Correlates with Erlotinib’s Effect on SN-38 Glucuronidation.European Journal of Cancer,2010, 46(11): 2097-2103.

(15)Liu Y, Ramirez J, House L, Ratain MJ. Comparison of the drug-drug interactions potential of erlotinib and gefitinib via inhibition of UDP-glucuronosyltransferases.Drug Metabolism and Disposition, 2010, 38(1): 32-9.

(16) Kamdem LK*,Liu Y*, Stearns V, Kadlubar SA, Ramirez J, Jeter S, Shahverdi K, Ward BA, Ogburn E, Ratain MJ, Flockhart DA, Desta Z.In Vitroandin VivoOxidative Metabolism and Glucuronidation of Anastrozole.British Journal of Clinical Pharmacology, 2010, 70(6): 854-69. (*: Co-first author)

(17) Li W,Liu Y, Zhang JW, Ai CZ, Xiang N, Liu HX, Yang L. Anti-androgen-independent Prostate Cancer Effects of Ginsenoside Metabolites: In Vitro Mechanism and Possible Structure-Activity Relationship Investigation.Archives of Pharmacal Research, 2009, 32(1): 49-57.

(18) Zhang YY,Liu Y, Zhang JW, Ge GB, Wang LM, Sun J, Yang L. Characterization of human cytochrome P450 isoforms involved in the metabolism of 7-Epi-paclitaxel.Xenobiotica,2009, 39(4):283-292.

(19) Zhang YY,Liu Y, Zhang JW, Ge GB, Liu HX, Wang LM, Sun J, Yang L. C-7 Configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes.Xenobiotica,2009, 39(12):903-14.

(20) Liu HX, Hu Y,Liu Y, He YQ, Li W, Yang L. CYP1A2 is the major isozyme responsible for paeonol O-demethylation in human liver microsomes.Xenobiotica, 2009, 39(9): 672-679.

(21) Liu HX, Hu Y,Liu Y, He YQ, Li W, Yang L. Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6.Xenobiotica, 2009, 39(5): 382-390.

(22) He YQ, Yang L,Liu Y, Zhang JW, Tang J, Su J, Li YY, Lu YL, Wang CH, Yang L, Wang ZT. Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry.Acta Pharmacologica Sinica, 2009, 30(10):1462-70.

(23) Liu HX, Hu Y, He YQ,Liu Y, Li W, Yang L. Ultra-performance liquid chromatographic- electrospray mass spectrometric determination (UPLC-ESI-MS) of O-demethylated metabolite of paeonol in vitro: Assay development, human liver microsome activities and species differences.Talanta, 2009, 79(5): 1433-1440.

(24) Hu Y, Luan HW, Liu HX, Ge GB, Zhou K,Liu Y, Yang L. The Acceptor Specificity and Transfer Efficiency of a β-Glycosidase from the China White Jade Snail.Bioscience, Biotechnology, and Biochemistry. 2009, 73(3):671-6.

(25) Hu Y, Luan HW, Ge GB, Liu HX, Zhang YY, Zhou K,Liu Y, Yang L. Deoxynojirimycin enhanced the transglycosylation activity of a glycosidase from the China White Jade Snail.Journal of Biotechnology. 2009, 139(3): 229-35.

(26) Dong PP, Zhang YY, Ge GB, Ai CZ,Liu Y, Yang L, Liu CX. Modeling resistance index of taxoids to MCF-7 cell lines using ANN together with electrotopological state descriptors.Acta Pharmacologica Sinica, 2008, 29(3):385-96.

(27) Liu HX, He YQ, Hu Y,Liu Y, Zhang JW, Li W, Wang ZT, Yang L. Determination of UDP-glucuronosyltransferase UGT2B7 activity in human liver microsomes by ultra-performance liquid chromatography with MS detection.Journal of Chromatography B, 2008, 870(1):84-90.

(28) Zhang JW, Ge GB,Liu Y, Wang LM, Liu XB, Zhang YY, Li W, He YQ, Wang ZT, Sun J, Xiao HB, Yang L. Taxane's substituents at C3' affect its regioselective metabolism-Different in vitro metabolism of cephalomannine and paclitaxel.Drug Metabolism & Disposition, 2008, 36(2):418-26.

(29) Li W,Liu Y, He YQ, Zhang JW, Gao Y, Ge GB, Liu HX, Huo H, Liu HT, Wang LM, Sun J, Wang Q, Yang L. Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes.Xenobiotica, 2008, 38(12): 1551–1565.

(30) Zhang JW,Liu Y, Zhao JY, Wang LM, Ge GB, Gao Y, Li W, Liu HT, Liu HX, Zhang YY, Sun J, Yang L. Metabolic profiling and P450 reaction phenotyping of medroxypro- gesterone acetate.Drug Metabolism and Disposition, 2008, 36(11): 2292-8.

(31) Liu HX,Liu Y, Zhang JW, Li W, Liu HT, Yang L. UDP-Glucuronosyltransferase 1A6 is the major isozyme responsible for protocatechuic aldehyde glucuronidation in human liver microsomes.Drug Metabolism and Disposition, 2008, 36(8):1562-9.

(32) Cao J,Liu Y, Jia L, Jiang LP, Geng CY, Yao XF, Kong Y, Jiang BN, Zhong LF.Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging.Journal of Agricultural and Food Chemistry, 2008, 56(24):12059-63.

(33) Cao J,Liu Y, Jia L, Zhou HM, Yang G, Jiang LP, Li QJ, Zhong LF. Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in Human Hepatoma G2 Cells.Free Radical Biology & Medicine, 2007, 43(6): 968-975.

(34) Zhang JW,Liu Y, Cheng J, Li W, Ma H, Liu HT, Sun J, Wang LM, He YQ, Wang Y, Wang ZT, Yang L. Inhibition of human liver cytochrome P450 by star fruit juice.Journal of Pharmacy and Pharmaceutical Sciences, 2007, 10 (4): 496-503.

(35) Cao J, Jiang LP,Liu Y, Yang G, Yao XF, Zhong LF. Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells.Toxicon, 2007, 49(8): 1219-1222.

(36)杨凌,刘洪涛,马红,刘勇,郝大程。系统生物学在中药ADME性质研究中的应用,《世界科学技术中医药现代化》, 2007, 9(1): 98-104.

(37)Liu Y, Zhang JW, Li W, Ma H, Sun J, Deng MC, Yang L. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes.Toxicological Sciences, 2006, 91(2): 356-364.

(38)Liu Y, Ma H, Zhang JW, Deng MC, Yang L. Influence of ginsenoside Rh1and F1on human cytochrome P450 enzymes.Planta Medica2006, 72(2): 126-131.

(39)Liu Y, Yang L. Early Metabolism Evaluation Making Traditional Chinese Medicine Effective and Safe Therapeutics.Journal of Zhejiang University SCIENCE B, 2006, 7(2): 99-106.

(40) Zhang JW,Liu Y, Li W, Hao DC, Yang L. Inhibitory effect of medroxyproges- terone acetate on human liver cytochrome P450 enzymes.European Journal of Clinical Pharmacology,2006, 62(7): 497-502.

(41) Li J,Liu Y, Zhang JW, Wei H, Yang L. Characterization of drug metabolizing activities in Chinese Bama minipig: comparison with human analogs.Comparative Medicine, 2006, 56(4): 286-290.

(42)Yang L,Liu Y, Liu CX.Metabolism and pharmacokinetics of ginsenosides.Asian Journal of Pharmacodynamics and Pharmacokinetics, 2006, 6(2): 103-120.

(43) Han QB, Yang L,Liu Y, Wang Y, Qiao C, Song J, Xu L, Yang D, Chen S, Xu H. Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects form Garcinia Hanburyi.Planta Medica, 2006, 72(3): 281-284.

(44) Cao J, Jia L, Zhou HM,Liu Y, Zhong LF. Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells.Toxicological Sciences, 2006, 91(2): 476-483.

(45)李健,刘勇,张江伟,魏泓,杨凌.贵州小型香猪与人5种CYP酶活性的比较.中国比较医学杂志,2006, 16(3): 157-161.

(46) He KJ,Liu Y, Yi Yang, Li P, Yang L. A dammarane glycoside derived from ginsenoside Rb3.Chemical & Pharmaceutical Bulletin, 2005, 53(2): 177-179.

(47)刘勇,李鹏,邓麦村,杨凌.普洛萨姆对大鼠肝微粒体细胞色素P450 3A酶动力学的影响.大连医科大学学报,2005; 27: 167-169.

(48)Liu Y, Li W, Li P, Deng MC, Yang SL, Yang L. The Inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity.Biological & Pharmaceutical Bulletin, 2004, 27(10): 1555-1560.

(49)刘勇,仲来福.大蒜素对顺铂所致大鼠肾损害的预防作用.中国公共卫生, 2003, 19(11): 1326-1328.

(50)刘勇,高岩松,仲来福.大蒜素、沙棘油、银杏叶提取物对顺铂所致大鼠肾损害预防作用的初步研究.大连医科大学学报. 2002, 24(1): 15-17.

参编著作:

(1) 曹军,艾纯芝,刘勇,乐卫东.第12章生物药物存在的问题及解决策略。生物药物与临床应用.王佃亮/乐卫东主编.人民军医出版社. 2015: 520-552. (ISBN:9787509182628)

(2)刘勇等.第四章药物代谢酶的诱导与抑制。中药药物代谢动力学研究思路与实践.刘昌孝主编.科学出版社.2013: 80-96.

(3)刘勇等.人参药代动力学性质。人参冠百草——人参化学、生物学活性和药代动力学研究进展.张均田主编.化学工业出版社. 2008: 53-71.

(4) Yang L,Liu Y, Liu CX. Pharmacokinetic Properties f Ginseng.In: Zhang JT, Chui DH, Chen CF.(Eds). The chemistry, metabolism and biological activities of ginseng. Beijing: Chemical Industry Press, China 2006, pp 59-86. (ISBN 7-5025-9164-8)

奖励

2006年辽宁省自然科学学术成果二等奖

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