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详细信息
夏杨柳
 

 

 

 

姓名夏杨柳

电子邮箱xiayangliu@dicp.ac.cn

 

学习经历:

2005.092009.07      大连理工大学,生物工程专业,工学学士

2009.092016.01      中国科学院大连化学物理研究所,生物化工专业,工学博士             

 

工作经历:

2016.03-至今         大连理工大学生命与医药学院,讲师

 

奖励:

第一届药代动力学朝阳论坛杰出奖(2015年)

 

研究领域(研究课题):

 

参与的科研课题

已结题项目

1. 儿茶酚甲基化酶抑制剂类药性优化及合作开发,参与人,国家国际科技合作专项项目

2012DFG32090),2012-201597

2. 香豆素儿茶酚类化合物的结构-代谢稳定性关系研究,参与人,国家自然科学基金(81001473),2011-201323.7

 

代表性论文(#共同第一作者)

1. Xia Yang-LiuGe Guang-BoWang PingLiang Si-ChengHe Yu-Qi, Ning Jing, Qian Xing-Kai, Li Yan, Yang Ling. Structural Modifications at the C-4 Position Strongly Affect the Glucuronidation of 6,7-Dihydroxycoumarins. Drug Metabolism and Disposition. 2015, 43(4): 553-560.

2. Xia Yang-Liu, Liang Si-Cheng, Zhu Liang-Liang, Ge Guang-Bo, He Gui-Yuan, Ning Jing, Lv Xia, Ma Xiao-Chi, Yang Ling, Yang Sheng-Li. Identification and Characterization of Human UDP-glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin. Drug Metabolism and Pharmacokinetics. 2014, 29(2): 135-140.

3. Wang Ping#, Xia Yang-Liu#, Yu Yang, Lu Jun-Xia, Zou Li-Wei, Feng Lei, Ge Guang-Bo, Yang Ling. Design, synthesis and biological evaluation of esculetin derivatives as anti-tumour agents. Rsc Advances. 2015: 5(66): 53477-53483.

4. Xin Hong#, Xia Yang-Liu#Hou Jie, Wang Ping, He Wei, Yang Ling, Ge Guang-Bo, Xu Wei. Identification and characterization of human UDP-glucuronosyltransferases responsible for the in-vitro glucuronidation of arctigenin. Journal of Pharmacy and Pharmacology. 2015, 67(12): 1673-1681.

5. Si-Cheng Liang, Yang-Liu Xia, Jie Hou, Guang-Bo Ge, Jiang-Wei Zhang, Yu-Qi He, Jia-Yue Wang, Xiao-Yi Qi, Ling Yang. Methylation, Glucuronidation, and Sulfonation of Daphnetin in Human Hepatic Preparations In Vitro: Metabolic Profiling, Pathway Comparison, and Bioactivity Analysis. Journal of Pharmaceutical Sciences. 2016, 105(2): 808-16.

6. 王梅玲, 夏杨柳, 杨梦丽, 吴大畅, 刘丽坤, 葛广波, 杨凌, 侯洁. O-葡萄糖醛酸苷的生物合成研究进展. 中草药. 2015, 46(7): 1065-1073.

7. Lv Xia, Hou Jie, Xia Yang-Liu, Ning Jing, He Gui-Yuan, Wang Ping, Ge Guang-Bo, Xiu Zhi-Long, Yang Ling. Glucuronidation of bavachinin by human tissues and expressed UGT enzymes: Identification of UGT1A1 and UGT1A8 as the major contributing enzymes. Drug Metabolism and Pharmacokinetics. 2015, 30(5): 358-365.

8. Zhu Liangliang, Xiao Ling, Xia Yangliu, Zhou Kun, Wang Huili, Huang Minyi, Ge Guangbo, Wu Yan, Wu Ganlin, Yang Ling. Diethylstilbestrol can effectively accelerate estradiol-17-O-glucuronidation, while potently inhibiting estradiol-3-O-glucuronidation. Toxicology and Applied Pharmacology. 2015, 283(2): 109-116.

9. Liang Si-Cheng, Ge Guang-Bo, Xia Yang-Liu, Zhang Jiang-Wei, Qi Xiao-Yi, Tu Cai-Xia, Yang Ling. In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis. Journal of Pharmaceutical Sciences. 2015, 104(10): 3557-3564.

10. He Guiyuan, Zhang Shixuan, Xu Liang, Xia Yangliu, Wang Ping, Li Shiyang, Zhu Liangliang, Xu Hongxi, Ge Guangbo, Yang Ling. C-8 Mannich base derivatives of baicalein display improved glucuronidation stability: exploring the mechanism by experimentation and theoretical calculations. RSC Advances. 2015, 5(109): 89818-89826.

11. Sun Dongxue, Zhu Liangliang, Xiao Ling, Xia Yangliu, Ge Guangbo, Cao Yunfeng, Wu Yan, Yin Jun, Yang Ling. In vitro glucuronidation of Armillarisin A: UDP-glucuronosyltransferase 1A9 acts as a major contributor and significant species differences. Xenobiotica. 2014, 44(11): 988-995.

12. Guo Bin, Fang Zhongze, Yang Lu, Xiao LingXia Yangliu, Gonzalez Frank J., Zhu Liangliang, Cao Yunfeng, Ge Guangbo, Yang Ling, Sun Hongzhi. Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases. Chemico-Biological Interactions. 2015, 231: 90-97.

13. 杨刚, 朱亮亮, 吕侠, 吴大畅, 夏杨柳, 马骁驰, 辛毅, 侯洁. Highly Efficient Preparation of Bisphenol A Glucuronide. Chemical Journal of Chinese Universities-Chinese. 2014, 35(2): 314-318.

14. Dong Rui-Hua, Fang Zhong-Ze, Zhu Liang-Liang, Ge Guang-Bo, Li Xiao-Bao, Hu Cui-Min, Cao Yun-Feng, Xia Yang-Liu, Yang Ling, Liu Ze-Yuan. Deep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms. Xenobiotica. 2013, 43(2): 133-139.

 

 

 

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