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彭智宇
 

 

 

姓名:彭智宇

职称:大连理工大学生命与医药学院兼职教授

办公电话:13662624605

电子邮箱:pengzhiyu@genomics.cn

 

学习经历:

2000.09-2004.07 中国农业大学,生物科学专业,学士

2004.09-2009.07 北京大学,生物信息学专业,博士     

 

科研经历:

深圳华大基因股份有限公司首席产品官(CPO),高级职称,《Frontiers in Genomics Assay Technology》杂志副编辑,广州市肿瘤贯穿组学研究重点实验室副主任。2015年获得“广东省特支计划-青年拔尖人才”荣誉称号。主持和参与了863计划、973计划、ICGC国际肿瘤基因组项目等重大科研项目。多项研究成果在NatureCell系列等国际顶级学术期刊发表,合计35篇,其中以第一作者、通讯作者发表12篇。

 

研究兴趣:

1.致力于将基因组学、转录组学、蛋白及代谢组学等多组学研究手段与临床相结合,探寻基因突变导致各种疾病的机制

和相对应的个性化治疗;

2.带领团队以大平台、大数据的方式开展出生缺陷及肿瘤的跨组学研究;

3.参与制定高通量基因组测序的国际标准及遗传病临床表型描述的中文标准;

4.带领团队开发基于基因组学的药物分析平台,为药物研发提供便利。

 

研究论文:

*为通讯作者#为第一作者

[1] Wenqian Zhang#, Ying Yu#, Falk Hertwig#, Jean Thierry-Mieg#, Wenwei Zhang#, Danielle Thierry-Mieg, JianWang,CesareFurlanello, ViswanathDevanarayan, Jie Cheng, Youping Deng, Barbara Hero, Huixiao Hong, MeiwenJia, Li Li,Simon M Lin, Yuri Nikolsky, André Oberthuer, Tao Qing, Zhenqiang Su, Ruth Volland, Charles Wang, May D. Wang,Junmei Ai, Davide Albanese, ShahabAsgharzadeh, SmadarAvigad, WenjunBao, Marina Bessarabova, Murray H. Brilliant, BenediktBrors, Marco Chierici, Tzu-Ming Chu, Jibin Zhang, Richard G. Grundy,Min Max He, Scott Hebbring,Howard L. Kaufman, Samir Lababidi, Lee J. Lancashire, Yan Li, Xin X. Lu, HengLuo, Xiwen Ma, BaitangNing, Rosa Noguera, Martin Peifer, John H. Phan, FrederikRoels, Carolina Rosswog, Susan Shao, JieShen, Jessica Theissen,Gian Paolo Tonini, Jo Vandesompele, Po-Yen Wu, Wenzhong Xiao, Joshua Xu, WeihongXu, JiekunXuan, Yong Yang,Zhan Ye, Zirui Dong, Ke K. Zhang, Ye Yin, Chen Zhao, YuantingZheng, Russell D. Wolfinger, Tieliu Shi, Linda H. Malkas, Frank Berthold, Jun Wang, Weida Tong, Leming Shi*, ZhiyuPeng*, and Matthias Fischer*. Comparison of RNA-seq and microarray-based models for clinical endpoint prediction.Genome Biology, 2015, 16(1): 1-12.

[2]ZhiyuPeng#*, Chengfu Yuan, Lucas Zellmer, Siqi Liu*, NingzhiXu*, and D. Joshua Liao*. Hypothesis: Artifacts, Including Spurious Chimeric RNAs with a Short Homologous Sequence, Caused by Consecutive Reverse Transcriptions and Endogenous Random Primers. Journal of Cancer, 2014, 6(6):555-567.

[3]Lin Kang#, Xiaoqiao Liu, Zhoulin Gong, HanchengZheng, Jun Wang, YingruiLi,Huanming Yang,  James Hardwick, Hongyue Dai, Ronnie T.P. Poon, Nikki P. Lee, Mao Mao, ZhiyuPeng*, Ronghua Chen.Genome-wide identification of RNA editing in hepatocellular carcinoma.Genomics, 2014, 105(2):76-82.

[4] JiaYuChen#, ZhiyuPeng#, RongliZhang#, XinZhuangYang, Bertrand ChinMingTan, HuayingFang, ChuJunLiu, Mingming Shi, ZhiQiang Ye, Yong E Zhang, MinghuaDeng, Xiuqin Zhang*, ChuanYunLi*. RNA editome in rhesus macaque shaped by purifying selection.PLoS Genetics, 2014, 10(4):72-73.

[5] Jikun Wu#, Wenqian Zhang#, Songbo Huang, Zengquan He, Yanbing Cheng,JunWang, Tak-Wah Lam, ZhiyuPeng* and Siu-Ming*.SOAPfusion: a robust and effective computational fusion discovery tool for RNA-seq reads. Bioinformatics, 2013, 29(23):2971-2978.

[6]Robert Piskol#, ZhiyuPeng#, Jun Wang and Jin Billy Li*.Lack of evidence for existence of noncanonical RNA editing.Nature Biotechnology, 2013, 31(1):19-20.

[7] Hui Li#, ZhiyuPeng#, Xiaohong Yang, Weidong Wang, Junjie Fu, Jianhua Wang, Yingjia Han,Yuchao Chai, TingtingGuo, Ning Yang, Jie Liu, Marilyn L Warburton, Yanbing Cheng,XiaominHao, Pan Zhang, Jinyang Zhao, Yunjun Liu, Guoying Wang*, Jiansheng Li*and Jianbing Yan*.Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels. Nature Genetics, 2012, 45(1):43-50.

[8]Shancheng Ren#, Zhiyu Peng#, Jian-Hua Mao#, Yongwei Yu, Changjun Yin, Xin Gao, Zilian Cui, Jibin Zhang, Kang Yi, Weidong Xu, Chao Chen, Fubo Wang, Xinwu Guo, Ji Lu, Jun Yang, Min Wei, Zhijian Tian, Yinghui Guan, Liang Tang, Chuanliang Xu, Linhui Wang, Xu Gao, Wei Tian, Jian Wang, Huanming Yang, Jun Wang and Yinghao Sun*. RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings. Cell Research, 2013, 23(5):732-732.

[9] ZhiyuPeng#, Yanbing Cheng#, Bertrand Chin-Ming Tan#, Lin Kang, ZhijianTian, Yuankun Zhu, Wenwei Zhang, Yu Liang, Xueda Hu, Xuemei Tan, Jing Guo, Zirui Dong, Yan Liang, Li Baoand Jun Wang*. Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Biotechnology, 2012, 30(3):253-260.

[10] ZhiyuPeng#, Xin Zhou, Linchuan Li, Xiangchun Yu, Hongjiang Li, Zhiqiang Jiang, Guangyu Cao, MingyiBai, Xingchun Wang, Caifu Jiang, Haibin Lu, XianhuiHou, LijiaQu, Zhiyong Wang, JianruZuo, XiangdongFu,Zhen Su, Songgang Li* and HongweiGuo*. Arabidopsis Hormone Database: a comprehensive genetic and phenotypic information database for plant hormone research in Arabidopsis. Nucleic Acids Research, 2009, 37(37):975-982.

 

专利成果:

[1] 章文蔚,张艳艳,龚梅花,彭智宇,韩祖晶,高欢,汪建,王俊,杨焕明,张秀清.(2015)一种分析基因表达定量的方法.授权号:ZL2011 1 0283718.2

 

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