盘锦校区生命与医药学院
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Yong Liu
 

Yong Liu Ph.D.

Tel: +86-427-2631433

Email: yliu@

Education

2002-2006 Ph.D. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China

1999-2002 M.S. Dalian Medical University, China

1989-1994 M.D. China Medical University, China

Research Areas

(1) Clinical pharmacology and individualized medication

(2) Drug metabolism and pharmacokinetics

(3) Toxicology

(4) Discovery and development of drugs

Current Major Research Funding

(1) National Science and Technology Major Project of China, Key techniques of quantitative detection of individual difference of drug reactions based on the new type probes. 2012-2015.

(2) National Science and Technology Major Project of China, Research of individualized drug therapy of liver cancer. 2012-2015.

Representative Publications

(#Co-first author,*Corresponding author)

(1) Li W, Xing Y,Liu Y*. Inhibition of SN-38 glucuronidation by gefitinib and its metabolite. Cancer Chemother Pharmacol, 2015, 75(6):1253-60.

(2) Cao YF, He RR, Cao J, Chen JX, Huang T,Liu Y*. Drug-Drug Interactions Potential of Icariin and Its intestinal metabolites via Inhibition of Intestinal UDP-Glucurono- syltransferases.Evidence-Based Complementary and Alternative Medicine. 2012: 395912, doi:10.1155/2012/395912.

(3)Liu Y, Jeong H, Takahashi H, Drozda K, Patel SR, Shapiro NL, Nutescu EA, Cavallari LH.Decreased Warfarin Clearance Associated With the CYP2C9 R150H (*8) Polymorphism.Clinical Pharmacology & Therapeutics2012; 91(4): 660-5.

(4)Liu Y, Ramirez J, Ratain MJ. Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors.British Journal of Clinical Pharmacology, 2011, 71(6): 917–920.

(5)Liu Y, Ramirez J, House L, Ratain MJ. The UGT1A1*28 Polymorphism Correlates with Erlotinib’s Effect on SN-38 Glucuronidation.European Journal of Cancer,2010, 46(11): 2097-2103.

(6)Liu Y, Ramirez J, House L, Ratain MJ. Comparison of the drug-drug interactions potential of erlotinib and gefitinib via inhibition of UDP-glucuronosyltransferases.Drug Metabolism and Disposition, 2010, 38(1): 32-9.

(7) Kamdem LK#,Liu Y#, Stearns V, Kadlubar SA, Ramirez J, Jeter S, Shahverdi K, Ward BA, Ogburn E, Ratain MJ, Flockhart DA, Desta Z.In Vitroandin VivoOxidative Metabolism and Glucuronidation of Anastrozole.British Journal of Clinical Pharmacology, 2010, 70(6): 854-69.

(8) Cao J,Liu Y, Jia L, Zhou HM, Yang G, Jiang LP, Li QJ, Zhong LF. Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in Human Hepatoma G2 Cells.Free Radical Biology & Medicine, 2007, 43(6): 968-975.

(9)Liu Y, Zhang JW, Li W, Ma H, Sun J, Deng MC, Yang L. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes.Toxicological Sciences, 2006, 91(2): 356-364.

(10)Liu Y, Ma H, Zhang JW, Deng MC, Yang L. Influence of ginsenoside Rh1and F1on human cytochrome P450 enzymes.Planta Medica2006, 72(2): 126-131.

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